Analytical Eco-Scale for Evaluating the Uniqueness of Voltammetric Method used for Determination of Antiemetic Binary Mixture Containing Doxylamine Succinate in Presence of its Toxic Metabolite

Abstract Green analytical procedures are gaining popularity in the pharmaceutical research area as a way to reduce environmental impact and improve analyst health safety. The current work presents green sensitive electrochemical carbon paste electrode that has been chemically modified with zirconium dioxide multi-walled nanotubes for estimation of pyridoxine HCl (PYR) doxylamine succinate (DOX) using square wave voltammetric technique. Under optimum conditions, linearity ranges were 20.00–2000.00 ng mL −1 2.00–20.00 µg both drugs 1st linear segment 2nd segment, respectively. Stability testing assesses how quality drug substance changes over time, depending on laboratory factors. DOX was found undergo oxidative degradation when refluxed 7 h 30% H 2 O degraded product (DOX DEG) (toxic metabolite) successfully characterized utilizing LC–MS. developed showed selectivity determination binary mixture pure form, presence DEG common interfering molecules good recovery. proposed method be eco-friendlier than reported terms use hazardous chemicals solvents, energy consumption, waste generation. Graphical